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Cynthia Brame

Assistant Professor, Department of Biology

Contact Information

254 Leo Avenue
Shreveport, LA 71105
Home Phone: (318) 865-5058
Work Phone: (318) 869-5097
Email: email

Education

Professional Experience

Publications

Webb DJ, Schroeder MJ, Brame CJ, Whitmore L, Shabanowitz J, Hunt DF, and Horwitz, AR. Paxillin phosphorylation sites mapped by mass spectrometry. J. Cell Science 118: 4925-4929, 2005.

Moran MF, White F, Marto J, Brame CJ, Ornatsky O, Ross M, Toledo-Sherman LM, Castro A, Duewel H, Hosfield C, Orsi C, Topaloglou T, Figeys D, Caldwell-Busby J, and Stover DR. Phospho-proteomics in drug discovery and development. Chapter in: Protein Tyrosine Kinase Inhibitors in Cancer Therapy. D. Fabbro and F. McCormick, eds. Humana Press, 2004.

Marto JA, Brame CJ, Ficarro SB, White FM, Shabanowitz J, and Hunt DF. Sequence analysis: Low energy MS/MS-Peptide Interpretation. Chapter in: Encyclopedia of Mass Spectrometry, Volume 2: Biological Applications. R. Caprioli and M. Gross, eds. Elsevier, 2004.

Marto JA, Brame CJ, Ficarro SB, White FM, Shabanowitz J, and Hunt DF. Chemical derivitization for peptide sequence analysis and consideration for sequence analysis of peptides subjected to posttranslational modifications. Chapter in: Encyclopedia of Mass Spectrometry, Volume 2: Biological Applications. R. Caprioli and M. Gross, eds. Elsevier, 2004.

Brame CJ, Moran MF, and McBroom-Cerajewski, LD. A mass spectrometry-based method for distinguishing between symmetrically and asymmetrically dimethylated arginine residues. Rapid Communications in Mass Spectrom. 18: 877-81, 2004.

Brame CJ, Boutaud O, Davies S, Yang T, Oates JA, Salomon RG, Roden DM, Morrow JD, and Roberts LJ, II. Modification of proteins by isoketal-containing oxidized phospholipids. J. Biol. Chem. 279: 13447-51, 2004.

Zarling AL, Luckey CJ, Marto JA, White FM, Brame CJ, Evans AM, Lehner PJ, Cresswell P, Shabanowitz J, Hunt DF, and Engelhard VH. Tapasin is a facilitator, not an editor, of class I MHC peptide binding. J Immunol. 171: 5287-95, 2003.

Davies SS, Brame CJ, Boutaud O, and Roberts LJ, II. Measurement of isoketal protein adducts by liquid chromatography electrospray tandem mass spectrometry. Chapter in: Methods in Biological Oxidative Stress. K. Hensley and RA Floyd, eds., pp 127-136, 2003.

Harnpicharnchai P, Jakovljevid J, Horsey E, Miles T, Roman J, Rout M, Meagher D, Imai B, Guo Y, Brame CJ, Shabanowitz J, Hunt DF, and Woolford JL, Jr. Composition and functional characterization of yeast 66S ribosome assembly intermediates. Mol Cell 8: 505-515, 2001.

Boutaud O, Li J, Chaurand P, Brame CJ, Marnett LJ, Roberts LJ, II, and Oates JA. Oxygenation of arachidonic acid by cyclooxygenases generates reactive intermediates that form adducts with proteins. Adv Exp Med Biol. 500:133-137, 2001.

Strahl BD, Briggs SD, Brame CJ, Caldwell JA, Koh SS, Ma H, Cook RG, Shabanowitz J, Hunt DF, Stallcup MR, and Allis CD. Methylation of histone H4 at arginine 3 occurs in vivo and is mediated by the nuclear receptor coactivator PRMT1. Curr. Biol. 11: 996-1000, 2001.

Boutaud O, Brame CJ, Chaurand P, Li J, Rowlinson SW, Crews BC, Ji C Marnett LJ, Caprioli RM, Roberts LJ, II, and Oates JA. Characterization of the lysyl adducts of prostaglandin H-synthases that are derived from oxygenation of arachidonic acid. Biochemistry 40: 6948-6955, 2001.

Mosammaparast N, Jackson KR, Guo Y, Brame CJ, Shabanowitz J, Hunt DF, and Pemberton LF. Nuclear import of histone H2A and H2B is mediated by a network of karyopherins, including Kap114p, Kap121p, Kap123p, and Kap95p. J. Cell. Biol. 153: 251-262, 2001.

Roberts LJ, II, Chen Y, Boutaud O, Davies SS, Morrow JD, Oates JA, and Brame CJ. Reactive products of the isoprostane pathway: isoketals and cyclopentenone A2/J2-isoprostanes. Chapter in: Advances in Prostaglanding and Leukotriene Research: Basic Science and New Clinical Applications. B. Samuelsson, R. Paoletti, GC Folco, E. Granstrom, and S. Nicosia, eds. Kluwer Academic Publishers, 2001.

Hsu J-Y, Sun Z-W, Li X, Reuben M, Tatchell K, Biship DK, Grushcow JM, Brame CJ, Caldwell JA, Hunt DF, Lin R, Smith MM, and Allis CD. Mitotic phosphorylation of histone H3 is governed by Ipl1/aurora kinase and Glc7/PP1 phosphatase in budding yeast and nematodes. Cell 102: 279-291, 2000.

Reich EE, Zackert WE, Brame CJ, Chen Y, Roberts LJ, II, Hachey DL, Montine TJ, and Morrow JD. Formation of novel D-ring and E-ring isoprostane-like compounds (D-4/E-4-neuroprostanes) in vivo from docosahexaenoic acid. Biochemistry 29: 2376-2383, 2000.

Roberts LJ, II, Brame CJ, Chen Y, and Morrow JD. Formation of novel reactive products via the isoprostane pathway. In: Proc. 5th Internat. Conf. On Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Other Related Diseases. KV Honn, S Nigam, L Marnett, and E Dennis, eds., Plenum Publishers, 2000.

Salomon RG, Sha W, Brame CJ, Kaur K, Subbanagounder G, O’Neil J, Hoff HF, and Roberts LJ, II. Protein adducts of iso4levuglandin E2 in oxidized low density lipoprotein. J. Biol. Chem. 274: 20271-20280, 1999.

Brame CJ, Boutaud O, Oates JA, and Roberts LJ, II. Characterization of lysyl adducts formed by the -ketoaldehyde prostanoids LGE2/D2. Biochemistry 38: 9389-9396, 1999.

Roberts LJ, II, Salomon RG, Morrow JD, and Brame CJ. New developments in the isoprostane pathway: identification of novel highly reactive -ketoaldehydes (isolevuglandins) and characterization of their protein adducts. FASEB J. 13: 1157-1168, 1999.

Roberts LJ, II, Brame CJ, Chen Y, Morrow JD, and Salomon RG. Formation of reactive products of the isoprostane pathway: isolevuglandins and cyclopenteneone isoprostanes. Adv. Exp. Med. & Biol. 469: 335-341, 1999.

Brame CJ, Salomon RG, Morrow JD, and Roberts LJ, II. Identification of extremely reactive -ketoaldehydes as products of the isoprostane pathway. J. Biol. Chem. 274: 13139-13146, 1999.

Roberts LJ, II, Brame CJ, Chen Y, and Morrow JD. Novel eicosanoids: Isoprostanes and related compounds. Methods Mol. Biol. 120: 257-285, 1999.

Morrow JD, Chen Y, Brame CJ, Yang J, Sanchez SC, Xu J, Zackert WE, Awad JA, and Roberts LJ, II. The isoprostanes: unique prostaglandin-like products of free radical-catalyzed lipid peroxidation. Drug Metab. Rev. 31, 117-139, 1999.

Subbanagounder G, Salomon RG, Murthi KK, Brame CJ, and Roberts LJ, II. Total synthesis of iso4-levuglandin E2. J. Org. Chem. 62: 7658-7666, 1997.

Invited Oral Presentations

Student Presentations of Collaborative Research

Honors, Awards, and Grants